Xylometazoline : instructions for use , price and analogues .Action during pregnancy .

Category Medicine | August 12, 2017 17:54

Composition 1 ml of drops 0.05% and 0,1% ksilometazolina 500 mg and 1 mg respectively.Sodium hydrogen phosphate, potassium dihydrogen phosphate, sodium chloride, benzalkonium chloride as auxiliary components.

1 ml spray 0,05% and 0,1% ksilometazolina 500 mg and 1 mg respectively.Sodium phosphate, benzalkonium chloride, disodium edetate dihydrate, potassium dihydrogen phosphate, eucalyptus oil, sodium chloride, macrogol glitserilgidroksistearat, sorbitol, glycerol, water as auxiliary components.

in 1 g of gel ksilometazolina 1 mg.Carbomer, glycerol , ammonia solution, ethanol, propylene glycol, methylparaben, propylparab

en, water as auxiliary components.

release form droplets in a concentration of 0.05% and 0.1%, 0.1% nasal gel, spray 0.05% and 0.1%.

Pharmacological action

Antikongestivnoe (local decongestant , vasoconstrictor ).

Pharmacodynamics and Pharmacokinetics: Pharmacodynamics

Xylometazoline - imidazoline derivative .Stimulates α1 and 2-adrenergic receptors of the blood vessels of the mucous nasopharynx.The result is that the blood vessels are narrowed, reduced redness, swelling and mucous discharge from the nose.This facilitates breathing through the nose when rhinitis , allergic conditions and diseases of the paranasal sinuses .Spray further comprises eucalyptus oil possessing anti-inflammatory and antibacterial effect, which is beneficial to decrease swelling of the nasal mucosa.Action manifested in 10-15 minutes and lasts for 8 to 10 hours.

Pharmacokinetics Study of pharmacokinetics in humans have been conducted.Sometimes the local application is sufficient suction for the appearance of systemic effects.

Indications

  • rhinitis of different etiology (allergic, viral, traumatic, bacterial);
  • rhinopharyngitis;
  • otitis media and evstahiit ;
  • to facilitate the discharge of secretions when sinusitis ;
  • to facilitate the diagnostic procedures in the nasal passages.

Contraindications

  • hypertension ;
  • angina ;
  • expressed atherosclerosis ;
  • tachycardia ;
  • thyrotoxicosis;
  • chronic rhinitis and atrophic pharyngitis ;
  • sensitization to the drug and increased sensitivity ;
  • prostatic hyperplasia ;
  • glaucoma ;
  • diabetes .

used with caution during pregnancy .In pediatrics unused drug concentration of 0.1%.

Side effects

  • burning in the nose and throat;
  • irritation of the mucous;
  • dry nasal mucosa;
  • sneezing ;
  • headache ;
  • dizziness ;
  • swelling of the nasal mucosa;
  • insomnia;
  • irregular heartbeat;
  • tachycardia ;
  • increase BP ;
  • increased excitability ;
  • blurred vision;
  • vomiting ;
  • depression .

for use xylometazoline Guide (Method and Dosage)

All forms of release of the drug is used intranasally.

xylometazoline nasal drops 0.1% used in adults, 1-2 drops in each course three times a day.

Spray 0.1% is used in adults by pressing 1 (corresponding to 0.1 mg) in each turn.The applicator is introduced, while maintaining the vertical position of the vial, and produce injection thrice a day for 8-10 hours.

Gel 0.1% is used for adults, 2-3 drops of the gel 3 times a day.

Given the possibility of systemic absorption and the appearance of adverse reactions on the application of xylometazoline instructions must be strictly observed.Apply the product in any form of release no more than 3-5 days.Do not use long-term and chronic rhinitis.If the peel in the nose appear better to use the drug in gel form.Missed dose subsequent dose is not doubled.

Overdose

manifested symptoms: mydriasis, cyanosis, nausea, vomiting, fever, tachycardia, arrhythmias, heart failure, respiratory failure, hypertension, pulmonary edema, mental disorders. Drowsiness , bradycardia, apnea and coma indicate suppression of the central nervous system.

Treatment: gastric lavage, sorbents, CPR, medications to lower blood pressure, anti-pyretic and anti-convulsants.

Interaction

Drugs stimulating the sympathetic system, enhance the effect.The drug should not be administered with MAO inhibitors and antidepressants, as they interact to provoke a hypertensive crisis.

Terms of sale is sold without a prescription.

storage conditions at a temperature below 250C.

Shelf life

3 years.

Xylometazoline pregnancy

To reduce nasal discharge during pregnancy can be used xylometazoline.Experience in the use of the drug in pregnant women is limited, but may be short-term use in minimal doses under strict medical supervision.Oxymetazoline
, despite the fact that it is also derived imidazoline is contraindicated in pregnancy.

Xylometazoline children

When acute rhinitis in children is not desirable to use a short-acting vasoconstrictor agents: naphazoline, tetryzoline, Ephedrine , because after their application is marked return swelling of the nasal mucosa.Preferably use a long-acting drugs: Xylometazoline ( Dlyanos , Otrivin ), oxymetazoline ( Nazivin ), Epinephrine ( Vibrocil )in order to reduce the multiplicity of applications.

Remember that a risk group in terms of drug poisoning imidazoline (Xylometazoline) are children up to 2 years.This drug is not recommended for use in neonates, infants and children up to 2 years.In rare cases, if there is no alternative, are appointed by the 0.05% drop for children up to 2 years.

For children older than 2 years is only 0.05% concentration of the drug, and the need to comply strictly metered, and the multiplicity of applications.

from 2 to 6 drops 0.05% 1 - 2 drop in each course of twice daily application permitted to 3 times a day if necessary.
6 to 12 years may be used 0.05% and 0.05% drop 2-3 drops of the spray or injection at each one stroke, but not more than 3 times a day.

Children older than 7 years appoint 0.05% gel - lay 3-4 times a day deep in each turn.

C12 years applied a drop of 0.1% and spray.

Please note that frequent and long-term (more than 5 days, some writers - more - 3 days), use of this drug can cause a pronounced decrease in local blood flow, resulting in an inadequate blood supply to the mucosa develops, up to atrophy in future.In this regard, do not use any form of drug release of more than 3 times a day and more than 3-5 days.

If there is a need for a nasal drops at a younger age, then Vibrocil approved for use in children with infants.Infants also used Nazivin 0.01%, at the age of 1 year - Nazivin 0.025%.

Analogs ksilometazolina

Matches code ATC 4th level:
  • Nazivin Sensitive children
  • Otrivin
  • Naphthyzinum
  • Noksprey
  • Sanorin
  • Lasolvan Reno
  • Dlyanos
  • Afrin
  • Rinorus
  • Evkazolin Aqua
  • Rinazolin
  • Grippostad Reno
  • Farmazolin
  • Tizin
  • Snoop
  • Nazol Advanced
  • Nazol Baby
  • Nazol Kids
  • Nazol

Analogues: Farmazolin, Farmazolin H Galazolin, Xylo-Mephala, Meralis, Otrivin, Otrivin with menthol and eucalyptus, Tizin Xylo .

Differences xylometazoline and oxymetazoline

xylometazoline and oxymetazoline belong to the group of imidazolines, acting on α1i2-adrenergic receptors and have a more lasting effect than preparations of phenylephrine : 10:00 action.

have prolonged drug effect occurs immediately, but after 10-15 minutes.Long vasoconstrictor effect allows you to use them 1-2 times a day, provides a peaceful night's sleep, but causes a greater risk of damage to the mucous membrane, up to atrophy.However, if you do not exceed the period of continuous use (3-4 days), the risk is reduced.

xylometazoline and oxymetazoline difference is only in duration.Xylometazoline relates to preparations with an average duration of action - 8-10 hours.Known drugs xylometazoline: Xylene, Rinostop, Galazolin, Xymelin, Otrivin, Farmazolin, Dlyanos, Tizin-Xylo .Oxymetazoline is a long-acting formulation - to 12 hours.Preparations based on it: Nazivin, Rinazolin, Nazol, Noksprey .To extend the vasoconstrictor action of the introduced high-prolongatory (cellulose ethers, alginates).

Reviews Reviews of using the drug for the most part positive, all point efficiency, duration of action, which is very convenient for a working day and the night.

drug drops is difficult to dose, as part of the solution enters the throat, so most side effects occur.In this regard, more reliable to use a metered spray.Many of the adverse reactions noted: insomnia, neurosis, agitation.

Other unpleasant phenomenon, which is often written in a review - rebound congestion, so-called « medical rhinitis ».Long-term use of the drug leads to the fact that the vasoconstriction is replaced by increasing blood flow and renewal of discharge.Resumed nasal congestion that does not respond to medical treatment.With prolonged use appears atrophy of the nasal mucosa .To avoid these undesirable effects of the drug is recommended to limit the use of up to three days.

Price ksilometazolina where to buy

Buy drug in Moscow pharmacies can be provided on the website of the Federal Service Help www.poisklekarstv.ru.Price xylometazoline drops 0.1% from 64 rubles.70 rub., in the form of spray 0,1% of 56 rubles.up to 64 rubles.

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