Konvuleks : instructions for use , price, reviews, side effects

Category Medicine | August 12, 2017 17:55


ampoule of 5 ml contains 500 mg valproatesodium (corresponding to 433.9 mg valproic acid ).

1 ml of syrup contains 50 mg of active substance. syrup is intended for treatment in pediatrics, so it is kind of fruity odor.Additional components: sodium cyclamate, methyl parahydroxybenzoate, peach or raspberry flavoring, sodium saccharin, liquid maltitol.

capsule contains 150, 300 or 500 mg of active substance.Additional components: hydrochloric acid, hydrogenated starch, sorbitol, Karion.

Product form

The drug is available in syrup form (form for children), capsules, drops, solution.

syrup and drops are available in bottles of 100 ml glass.T

he pack is made of cardboard 1 bottle and a special device for dispensing.

blister pack contains 10, 20 capsules.The pack of cardboard 5, 10 blisters.

solution produced in ampoules 5 ml, packed in packaging with a polymeric mesh.The stack of cardboard 5 vials.

Pharmacological action

antiepileptics , containing valproate Na. anticonvulsant effect provides 2 mechanisms of effects on the nervous system.Direct mechanism is based on improving the concentration of valproate in the nervous system;indirect - on modifications neurotransmitters , the impact on the membrane and the accumulation of metabolites of the active substance.

Pharmacodynamics and pharmacokinetics

After receiving valproate logged raising gamma-aminobutyric acid .The treatment reduced the period of the interim phase of sleep, increased REM sleep time.The active ingredient passes into breast milk to pass through both the blood-barrier , and the blood-brain.The highest concentration observed in the extracellular fluid and plasma.In the blood and cerebrospinal fluid accumulates the same amount of valproate.

binding to plasma proteins is dependent on the dose of medication (80-95%). Metabolism active substance is carried out in the hepatic system.When hemodialysis from the body displays only the free fraction.In the pathology of the liver slows down time Withdrawal because of low metabolism.


The drug is prescribed for all types of generalized seizures :

  • clonic;
  • tonic;
  • tonic-clonic.

The drug is used in the form of focal epilepsy (with and without secondary generalization).When bipolar disorders and manic syndrome also used valproic acid.

in pediatric patients for the prevention of recurrent febrile seizures appoint syrup Konvuleks (with the ineffectiveness of therapy with benzodiazepines).

solution is used for short-term treatment of epilepsy in individuals who for some reason can not accept Konvuleks tablets.


  • porphyria ;
  • severe hepatic pathology system, pancreas ;
  • individual hypersensitivity ;
  • severe thrombocytopenia (drop in platelet );
  • hemorrhagic diathesis .

wary valproic acid prescribed for:

  • suppression of bone marrow hematopoiesis (anemia, leukopenia);
  • pathology of renal system;
  • pancreatic diseases phase compensation;
  • in severe types of seizures (in pediatrics);
  • therapy other antiepileptic drugs;
  • gipoproteinemii ;
  • brain lesions (organic form);
  • congenital enzimopatii .

Konvuleks Side effects (adverse reactions)

Adverse reactions are recorded in combined therapy and valproic acid concentrations greater than 100 mg / l.

Digestive tract:

  • anorexia (or on the contrary, increased appetite);
  • vomiting;
  • hepatitis;
  • gastralgia;
  • constipation ;
  • nausea;
  • pancreatitis .

Nervous system:

  • ataxia ;
  • dizziness ;
  • coma ;
  • impaired consciousness;
  • migraine headache ;
  • drowsiness;
  • encephalopathy ;
  • dysarthria;
  • stupor.

Rarely patients changing mood, style of behavior and mental state:

  • hallucinations ;
  • fatigue;
  • depressed mood ;
  • excitement;
  • psychosis;
  • hyperactive state;
  • irritability.

Endocrine System:

  • increase breast;
  • secondary form amenorrhea ;
  • dysmenorrhea ;
  • galactorrhea.

Side effects from the senses:

  • nystagmus;
  • diplopia;
  • «flies".

Less changes are recorded by the system hemostasis , metabolic, allergic responses , alopecia (reversible reaction), peripheral edema .

Instructions on Konvuleks (Method and Dosage)

Syrup take per os during a meal (postprandial allowed).The kit includes a special metering device, which is produced by means of dosing.The daily amount of valproic acid is recommended to be divided into 3 stages.Selection of doses is carried out taking into account the age and weight of the child and related diseases.In the treatment of other medications aimed at arresting convulsions Konvuleks dosing is carried out for 15 days.Evaluating the results of the treatment, carried out every 2-3 days as monotherapy dose adjustment.

capsules intended for oral administration during a meal (after allowed).Inadmissible opening capsules and grinding.The daily dose can be divided into 2 admission.Dosing is carried out on an individual basis, the titration is carried out for a month with combined therapy;monotherapy - 7 days.Calculation of the daily dose is performed according to the scheme of 10-15 mg / kg.Titration is carried out taking into account the plasma concentration of the active ingredient in the blood, portability, efficiency, control epipristupami.

Konvuleks instructions for use in the form of a solution: the medicament is administered intravenously, together with a special solvent or as a bolus infusion.The Ringer's solution can act as a solvent.The daily dose is calculated by the scheme - 20-30 mg / kg.

drops administered 2-3 times per day with meals.The initial daily dose - 10/15 mg / kg.Then every 4 days to increase the dose of 200 mg.

Overdose Symptoms manifested in a dose dependent manner.In mild cases noted drowsiness , nausea , dizziness , sedation .In severe intoxication inhibited respiration, develops hyporeflexia, metabolilichesky acidosis , cramps, giptonus.Rarely develops cerebral edema and increase intracranial pressure .Assign chelators , spend posindromnuyu therapy.


not recommended to prescribe drugs that induce seizures or reduce seizure threshold .Not to prescribe antipsychotics, fenotiazinaminov.Carbapenem, Aztreonam and St. John's wort reduces the effectiveness of the drug, increasing the risk of seizures.Phenobarbital and Carbamazepine reduces the level of valproic acid.Konvuleks slows down felbamate.It should tell your doctor about all the medicines reception prior to the selection of a dose of valproic acid.

Terms of sale strictly on prescription.


Terms Solar radiation destroys the structure of the solution and syrup.Temperature range: 15-25 degrees.

Shelf life

capsules, solutions and syrups can be stored 5 years.Ready solution loses its effectiveness through the day.


Matches code ATC 4th level:
  • Gammalon
  • Depakine Chronosphere
  • Depakine
  • Depakine enteric 300
  • Depakine Chrono
  • Depakine;
  • valparin;
  • Keppra;
  • Enkorat;
  • Konvulsofin.


Prolonged tablet formulations are contraindicated for children under 3 years.In pediatric practice, a syrup.

during pregnancy (and lactation)

anticonvulsant therapy with valproic acid requires maximum protection from pregnancy .Experimental animal studies have revealed marked teratogenic influence active substance.In 2% of cases detected defects in development of the nervous system in children who were born to women who took Konvuleks I trimester.Therefore patients expedient appointment of folic acid.With a high probability of seizures dose of valproic acid is prescribed minimum, and override other anticonvulsant drugs.Mandatory monitoring of valproic acid in the blood index.

reviews Konvuleks (opinion of the patients and doctors)

The drug is actively used in neurological practice to prevent epipripadkov.Portals contain a variety of patient testimonials.Most of them describe all the negative symptoms, which may accompany the course of anticonvulsant therapy.We describe the situation when, unable to bear the adverse reactions, patients independently canceled the drug and then again returned to seizures, changing the usual style and way of life of patients.

pediatric neurologists prescribe the most accessible form of the drug - Konvuleks syrup for children.Reviews parents confirm the high efficacy of the drug in the treatment of epilepsy, because the number and severity of attacks are significantly reduced, despite the negative effect of valproic acid on the mental abilities of children.

Price Konvuleks where to buy

antiepileptic cost depends on the dosage form, the sales region and network of pharmacies.Price Konvuleks in tablet form - 500 rubles (500 mg, 50 pieces), as a solution - 1400 rubles.

online pharmacy Russian


  • Konvuleks syrup 50mg / ml 100ml Gerot Pharmazeutika / GLpharma
    136.00 rubles. order
  • Konvuleks tablets 500mg prolonged 50pcs G.L.Farma GmbH / Gerota Farmatsoytika GmbH
    527.00 rubles. order
  • Konvuleks Tablets 300mg 50 pieces G.L.Farma GmbH / Gerota Farmatsoytika GmbH
    341.00 rubles. order

Pharmacy IFC

  • Konvuleks drops 300mg / ml 100ml vials, Gerot Pharm./ Scherer GmbH Austria
    197.59 rubles. order
  • Konvuleks syrup w / children 50mg / ml 100ml vials, Gerot Pharm./ Scherer GmbH Austria
    135.70 rubles. order
  • Konvuleks TBL n / a retard 300mg №50, Gerot Pharm./ Scherer GmbH Austria
    327.96 rubles. order
  • Konvuleks TBL n / a retard 500mg №50, Gerot Pharm./ Scherer GmbH Austria
    559.40 rubles. order


  • Konvuleks 500mg N50 prolong tab G.L.Farma GmbH / Gerota Farmatsoytika GmbH
    572 rubles. order
  • Konvuleks 300 mg N50 Table G.L.Farma GmbH / Gerota Farmatsoytik
    348 rubles. order
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online pharmacy Ukraine


  • Konvuleks capsules 500mg №100 Gerota Pharmaceuticals (Avstiya)
    329.22 UAH. order
  • Konvuleks solution for injection ampoules 5 ml of N 5 Gerota Pharmaceuticals (Avstiya)
    871.40 UAH. order
  • Konvuleks retard coated tablets 300mg №50 Gerota Pharmaceuticals (Avstiya)
    190.51 UAH. order
  • Konvuleks Gerot Pharmazeutika (Austria)
    235.62 UAH. order
  • Konvuleks 50mg / 1ml Syrup for kids 100 ml Gerota Pharmaceuticals (Avstiya)
    65.37 UAH. order
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Online Pharmacy Kazakhstan


  • Konvuleks 50 mg / ml syrup 100 ml Children. G. L. Pharma GmbH (Austria)
    1415 n. order
  • Konvuleks 150 mg №100 kaps.rastvor. / Intestinal. G. L. Pharma GmbH (Austria)
    1510 n. order
  • Konvuleks 500 mg №100 kaps.rastvor. / Intestinal. G. L. Pharma GmbH (Austria)
    3070 n. order
  • Konvuleks 300 mg / ml, 100 ml drops d / ingestion G. L. Pharma GmbH (Austria)
    1485 n. order
  • Konvuleks 300 mg №100 kaps.rastvor. / Intestinal. G. L. Pharma GmbH (Austria)
    2135 n. order
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