Tablets and syrup Pantogam : instructions for use , price , reviews, children's and baby .Analogs

Category Medicine | August 12, 2017 17:55


INN (international nonproprietary name) - hopantenic acid.

Tablets Pantogam

1 tablet contains 250 mg or 500 mg hopantenic acid - active substance.

Auxiliary ingredients respectively the weight content of the active substance:

  • 3,1 mg or 6.2 mg - calcium stearate;
  • 0,8 mg or 1.6 mg - methylcellulose;
  • 9,3 mg or 18.6 mg - talc;
  • 46,8 mg - 93.6 mg - magnesium hydroxycarbonate.

Syrup Pantogam

1 vial contains 10 g / 100 ml hopantenic acid - active substance.

Auxiliary ingredients:

  • 15 g - sorbitol;
  • 25,8 g - glycerol;
  • 0,1 g - citric acid monohydrate;
  • 0,05 g - aspartame;
  • 0,1 g - sodium benzoate;
  • 0,01 g - Spices "Cherry 667";
  • to 100 ml - purified water.

Product form

Pantogam drug produced in the form:

  • spigot white tablets of 250 mg or 500 mg, with Valium and a facet, 50 tablets per pack;
  • syrup colorless or slightly yellow, with the smell of cherry, 1 bottle of 100 ml pack.

Pharmacological action


Pharmacodynamics and pharmacokinetics

Pantogam drug has a spectrum of action due to the presence in its structure neurotransmitter GABA .Directly affects GABA (subtype B) receptor channel complex.Shows anticonvulsant and nootropic activity , increases brain resistance to the toxic effects and hypoxia. In neurons activates anabolic processes, reduces the excitability of the motor, stimulates physical performance and mental activity of the organism, combines moderate sedation with a mild stimulating effect.

When alcohol intoxication chronic nature, as well as the refusal of alcohol enhances GABA metabolism . Shows ability to oppression reactions acetylation , who are involved in the mechanism of inactivation sulfonamides, and procaine (Novocain) , resulting in prolonged their action.Prevents abnormal increase cystic reflex and strengthening detrusor tone.

When taken orally hopantenic acid rapidly absorbed from the gastrointestinal tract, has the ability to pass through the blood-brain barrier , creates the highest concentration in the walls of the stomach, liver, skin and kidneys.

not susceptible to metabolism and displayed for 2 days in an unmodified form.Since feces shows 28.5% product and 67.5% in urine.

Indications Pantogam

Indications Pantogam tablets for adults and children from 3 years:

  • cognitive impairment with neurotic disorders , and also due to organic damagebrain (including head injuries and the consequences neuroinfections);
  • extrapyramidal pathology (hepatolenticular degeneration, parkinsonism, myoclonus, epilepsy, Huntington's chorea etc. .);
  • cerebrovascular insufficiency provoked atherosclerotic vascular abnormalities in brain structure ;
  • prevention, as well as conducting therapy extrapyramidal syndrome (akinetic, hyperkinetic), because neuroleptics reception;
  • epilepsy, flowing with inhibition of mental processes (administered in combination with an anticonvulsant drug action);
  • excessive psycho-emotional stress, decreased physical performance and mental alertness, to improve memory and concentration;
  • neurogenic changes during urination (enuresis, frequent urination, imperative incontinence, urgency);
  • organic cerebral insufficiency in schizophrenia;
  • children from 3 years prescribed pills Pantogam at perinatal encephalopathy, mental retardation of varying severity, delayed motor, speech, mental development or a combination thereof. also in various forms of cerebral palsy, neurosis pathologies (tics, stuttering), hyperkinetic manifestations (hyperactivity syndrome when there is a lack of attention).

Indications Pantogam children at birth, in the form of syrup:

  • perinatal encephalopathy (assigned at birth);
  • ICP different shapes of gravity;
  • mental retardation varying degrees of severity, including behavioral disorders;
  • pathology psychological status (delay of mental or physical, specific pathology of motor function, speech, and combinations thereof);
  • development skills school children (writing, reading, counting and so on.);
  • senile dementia in primary forms;
  • hyperkinetic deviation, including hyperactivity attention deficit;
  • lowering mnestiko-intellectual activity due to arteriosclerotic vascular pathologies of the brain;
  • injury, toxic or neuroinfec- tive impact on the brain;
  • neurosis state ( stuttering, inorganic encopresis, tics);
  • cerebral organic pathology in schizophrenia (in conjunction with psychotropic drugs );
  • extrapyramidal disease (Parkinson's disease, Huntington's syndrome, hepatolenticular degeneration, myoclonus epilepsy and so forth.);
  • therapy and prophylaxis extrapyramidal syndrome, due to receiving antipsychotics;
  • reduction of efficiency, both physical and mental, psycho-emotional overload, in order to improve memory and concentration;
  • epilepsy braking mental processes and reduced cognitive efficiency (in combination with anticonvulsants);
  • neurogenic bladder disorders etiology.


Abstract on drug Pantogam indicates the following contraindications to its use.

For tablets:

  • patient under the age of 3 years;
  • period breastfeeding ;
  • period pregnancy .

For the syrup:

  • first trimester of pregnancy;
  • phenylketonuria, because of the content of aspartame composed syrup.


  • hypersensitivity to hopantenic acid or other ingredients of the syrup or tablets;
  • acute kidney disease in a severe form.

Side effects

Typically, therapy with the use of Pantogam passes without serious complications.

There may be side effects in the form allergic reactions (rash on the skin, conjunctivitis, rhinitis) .In this case, reduce the dose or cancel Pantogam therapy with its use.

also observed noise in the head, sleep disturbances and daytime sleepiness phases. These symptoms usually do not require discontinuation of therapy and are transient.

Pantogam Instruction Usage (dosage and method)

Pantogam medicine in the form of syrup and tablets administered orally (p.o.) after meals, after 15-30 minutes.

preferred time of reception - up to 16 hours of the day.

Pantogam tablets, instructions for use:

recommended single dose Pantogam in tablet form for adults - 250 mg - 1000 mg daily dose equals - 1500 mg - 3000 mg.Babies with

3 years prescribed tablets in a single dose of from 250 mg to 500 mg, the daily dosage is equal to - 750 mg - 3000 mg.

course of treatment usually takes 30 to 120 days, in some cases up to six months.After 3 or 6 month break, you can spend a second course of treatment.

In the combination therapy of epilepsy Pantogam administered in a daily dose of 750 mg - 1000 mg, for a year or more.

In the combined treatment of extrapyramidal syndrome, neuroleptic take up to 3 grams of the drug, for several months.

In carrying out the combination therapy of extrapyramidal hyperkinesis in patients with hereditary pathological conditions nervous system recommended daily dose of 500 mg to 3000 mg, for up to 4 months or more.

To mitigate the effects of brain injury and neuroinfections - 0.25 g (250 mg) Pantogam with taking 3 - 4 times a day.

to resume performance in states of fatigue and excessive loads - 3 times a day 250 mg.

therapy for extrapyramidal syndrome, due to receiving neuroleptics , recommended for adult patients at 500 mg - 1000 mg, three times a day;recommended dosage for children - from 250 mg to 500 mg in 3-4 hours.The treatment lasts from 1 to 3 months.

Children with tics administered 3-6 times per day at a dose of 250 mg to 500 mg, for from 1 to 4 months.

When violations during urination adult patients take pills Pantogam 2-3 times during the day, 500 mg - 1000 mg;pediatric patients on 250 mg - 500 mg (daily dose recommended ranges from 25 mg to 50 mg per kilogram of body weight).The course of treatment is carried out for the 1 st - 3 months.

Depending on age, children with various diseases of the nervous system, administered from 1 to 3 g Pantogam.

dosage regimen often boils down to capacity dose for 7-12 days, followed by a reception Pantogam maximum dose for 15-40 days, with a slow reduction of the maximum dose (7-8 days) to the full withdrawal of the drug.

In case of need to re-treat, a break must be from 1 to 3 months.

Syrup Pantogam, instruction manual:

Adult patients administered a single dose of 250 mg - 1000 mg daily dosage equal to 1500 mg - 3000 mg.

children from 0 months recommend a single dose of 250 mg - 500 mg daily dose is equal to 750 mg - 3000 mg.

Therapy is conducted for from 1 to 4 months, at least up to 6 months.Reappointment Pantogam possible after a break of 3-6 months.

recommended daily dose range for the children, depending on the age and the pathology is:

  • from 0 to 12 months - 500 mg - 1000 mg;
  • up to 3 years - 500 mg - 1250 mg;
  • from 3 to 7 years - 750 mg - 1500 mg;
  • older than 7 years - 1000 mg - 2000 mg.

Tactics therapy recommended daily intake capacity for 7 -12-day, followed by a reception the maximum dose for a 15 - 40-days or more, with a gradual reduction in dose (7-8 days) todrug withdrawal.The course of treatment is 30 to 90 days (for the treatment of certain diseases to 6 months or more).

When combined epilepsy therapy with parallel receiving anticonvulsants administered 750 mg - 1000 mg per day.The treatment lasts for 12 months or more.

In the combined treatment of schizophrenia with a joint reception of psychotropic drugs recommend 500 mg-3000 mg per day, with a course of treatment from 30 days to 3 months.

the treatment of neuroleptic syndrome with associated extrapyramidal disorders, take the daily dose is up to 3,000 mg of syrup.The therapy is carried out for several months.

In therapy the effects of TBI and neuroinfections administered in a daily dosage of 500 mg to 3000 mg.

When extrapyramidal hyperkinesis, for the treatment of patients with organic disease of the nervous system, recommended daily dose of syrup from 500 mg to 3000 mg.The course of treatment up to 4 months or more.

reception syrup to restore operability asthenia and excessive loads performed three times a day in a dose of 250 mg - 500 mg.

Children with disorders of urination appoint 250 mg - 500 mg, a daily dose of equals - 25 mg - 50 mg per kilogram of body weight.The course of treatment lasts for a duration of 30 days up to 3 months;Adult shown syrup receive 2-3 times a day, 500 mg - 1000 mg.

When conducting long-term therapy is not recommended concurrent prescribing of drugs with the same effects.

Overdose If overdose pantogam symptoms may increase its side effects, in particular: noise in the head, drowsiness, or sleep disturbance.

Recommend symptomatic therapy with gastric lavage and the appointment activated carbon.


Pantogam, in combined with the admission of barbiturates prolongs their action.

a joint application with anticonvulsant enhances their effectiveness.

Warns side effects carbamazepine, phenobarbital, neuroleptics.

Potenziruet drugs effects local anesthesia (Procaine).

Action Pantogam enhanced by the combined treatment with etidronovoy acid and glycine.

Terms of sale in pharmacies by prescription.

Storage Conditions To be stored at a temperature not exceeding 25 ° C.

Shelf life

Tablets - 4 years.

syrup - 2 years.

Analogs Pantogam

Matches code ATC 4th level:
  • Vinpocetine
  • Tserebrokurin
  • Cavintonum Forte
  • Calcium Gopantenat
  • Tsefabol
  • Tserebrolizat
  • Pramistar
  • Vinpotropil
  • Sidnokarb
  • Lutset
  • Glycine
  • Glycine Forte Evalar
  • Glycine Bio
  • Glycine Ozone
  • Glycine VIS
  • Pantokaltsin
  • Cere
  • Noben

When looking for alternative medicines you can offerThe following analogues Pantogam:

  • Vinpocetine;
  • Ginkgo Biloba;
  • Glycine;
  • Cavintonum;